MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019562
Disease: Von Hippel-Lindau Syndrome
Von Hippel-Lindau Syndrome 		0.010 GeneticVariation disease BEFREE These findings (a) represent the first example of genetic modifiers of RCC risk in VHL disease, (b) replicate a previous report of an association between MMP1/MMP3 variants and sporadic RCC and (c) further implicate MMP1/MMP3-related pathways in the pathogenesis of familial and sporadic RCC. 19551141 2009
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 GeneticVariation group BEFREE The aim of this work was to establish an association between the single-nucleotide polymorphisms (SNPs) of TGFB1 (rs1800471), AT (rs3789679), MMP-1 (rs17886084), MMP-3 (rs35068180), and PAI-1 (rs1799889) and the histological grading of necroinflammation, staging of hepatic fibrosis, and liver function in Mexican patients with advanced liver fibrosis due to chronic hepatitis C virus infection. 23941979 2013
CUI: C0276138
Disease: Viral myocarditis
Viral myocarditis 		0.010 Biomarker disease BEFREE Thus, Ginkgo biloba extract may be a promising therapeutic approach against VMC because it improved myocardial injury and alleviated the degree of myocardial fibrosis through suppression of S100A4 and MMP-3. 31359441 2019
CUI: C0242698
Disease: Ventricular Dysfunction, Left
Ventricular Dysfunction, Left 		0.010 Biomarker phenotype LHGDN MMP-3 is associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after AMI. 18234553 2008
CUI: C0042487
Disease: Venous Thrombosis
Venous Thrombosis 		0.200 Biomarker phenotype RGD Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis. 20515599 2010
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.010 GeneticVariation phenotype BEFREE Using a single-marker 'uncorrected' analysis, CCR5 A(-2459)G [rs1799864], MMP3 5A(-1171)6A [rs3025058] and PON1 gln192arg [rs662] gene variants were associated with increased risk, and CETP C(-629)A [rs1800775] gene variant with reduced risk of recurrent VTE, respectively. 19263529 2009
CUI: C0340766
Disease: Venous hypertension
Venous hypertension 		0.010 Biomarker disease BEFREE To explore the effect of doxycycline in VH-related angiogenesis, as well as the role of matrix metalloproteinase-3 (MMP-3) and other molecular factors. 29462373 2018
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.010 Biomarker phenotype BEFREE We investigated whether gene polymorphisms of Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and matrix metalloproteinase 3 (MMP3) are associated with increased vascular calcification in patients with type 2 diabetes (T2D) and evaluated whether serum MMP3 and osteoprotegerin (OPG) levels are related to calcification. 20092902 2010
CUI: C0042345
Disease: Varicosity
Varicosity 		0.030 AlteredExpression disease BEFREE Matrix metalloproteinases (MMPs), including MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9, and tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP-3 are upregulated in varicose veins. 19847861 2009
CUI: C0042345
Disease: Varicosity
Varicosity 		0.030 GeneticVariation disease BEFREE The MMP1-1607dupG and MMP3-1171dupA promoter polymorphisms are not valuable markers of susceptibility for varicose veins. 19508478 2009
CUI: C0042345
Disease: Varicosity
Varicosity 		0.030 Biomarker disease BEFREE Fibronectin, a potential substrate of MMP3, was decreased in SMC from varicose veins. 16088212 2005
CUI: C4721509
Disease: Usual Interstitial Pneumonia
Usual Interstitial Pneumonia 		0.300 Therapeutic disease CTD_human Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s). 28434932 2017
CUI: C0178879
Disease: Urinary tract obstruction
Urinary tract obstruction 		0.010 GeneticVariation disease BEFREE MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. 24414606 2014
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.020 Biomarker disease BEFREE For MMP3, G was undertransmited among affected progeny (p=0.019) in cleft palate subgroup. 25463899 2015
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.020 GeneticVariation disease BEFREE Polymorphisms in MMP3 (rs522616) and TIMP2 (rs8179096) showed significant association with all cleft types (all clefts, cleft lip/palate, and cleft palate; p ≤ 0.002). 22730240 2012
CUI: C3843756
Disease: Ulcerative colitis or Crohn's
Ulcerative colitis or Crohn's 		0.010 AlteredExpression disease BEFREE Myofibroblasts derived from normal mucosa and from mucosa affected by ulcerative colitis or Crohn's disease also expressed matrix metalloproteinase (MMP)-1, MMP-2, and MMP-3 but did not express MMP-9. 12651627 2003
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 AlteredExpression disease BEFREE MMP-1 and MMP-3 mRNA expression correlated well with the histological degree of acute inflammation, resulting in more than 15-fold increased MMP-1 and MMP-3 mRNA levels in inflamed versus normal colon samples from patients with ulcerative colitis and Crohn's disease. 10861266 2000
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 GeneticVariation disease BEFREE We found no general associations of the MMP-1 and MMP-3 genes to PSC or UC among Norwegian patients, but specific alleles were associated to subsets of PSC patients with UC and cholangiocarcinoma. 15288468 2004
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). 18485900 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE Altogether, we showed an inverse mechanistic relationship between IRF8 and MMP3 expression in tumor progression. 26008967 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 Biomarker phenotype BEFREE Evidence has shown that matrix metalloproteinases-3 (MMP3) is important for cancer progression. 24489939 2014
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE To the best of our knowledge, this is the first study to demonstrate the crucial role of reactive oxygen species in the switching expression of MMP-3 in stromal fibroblasts and prostate cancer cells during tumor progression, clarifying how the tumor microenvironment modulates ECM homeostasis control. 28831065 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 GeneticVariation phenotype BEFREE The results do suggest that, in women with breast cancer, a high-expressing MMP-3 genotype may promote tumor progression more effectively. 17922906 2007
CUI: C0598935
Disease: Tumor Initiation
Tumor Initiation 		0.010 Biomarker phenotype BEFREE Although MMP3 expression was originally linked to tumor initiation, the role of MMP3 beyond this stage has remained unclear. 26008967 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 AlteredExpression phenotype BEFREE Importantly, knockdown of Thbs2 led to increased MMP3 expression and interruption of the ERα mediated invasion suppression, providing further evidence of an ERα-Thbs2-MMP3 axis in CAF. 24374826 2014